ABSTRACT
Colorectal cancer (CRC) incidence in Puerto Rico has increased prodigiously since incidence figures were first recorded in 1950. Implications for hereditary nonpolyposis colorectal cancer (HNPCC) in concert with this increased CRC incidence are discussed. A family with the Amsterdam-positive criteria of the Lynch syndrome II variant, identified in the eastern area of Puerto Rico, is described. As far as we can determine, this is the first such report of this disorder in Puerto Rico
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology , Adjuvants, Immunologic/administration & dosage , Adjuvants, Immunologic/therapeutic use , Antimetabolites, Antineoplastic/administration & dosage , Antimetabolites, Antineoplastic/therapeutic use , Drug Therapy, Combination , Follow-Up Studies , Fluorouracil/administration & dosage , Fluorouracil/therapeutic use , Incidence , Levamisole/administration & dosage , Levamisole/therapeutic use , Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis , Colorectal Neoplasms, Hereditary Nonpolyposis/drug therapy , Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , Colorectal Neoplasms/epidemiology , Pedigree , Puerto Rico/epidemiology , Time FactorsABSTRACT
During the last 41 years cancer of the colon in Puerto Rico has markedly increased as reported by the Puerto Rico Cancer Registry. The etiology of this increase remains elusive, but possibilities include an increase in reporting new cases, dietary modifications, exposure to carcinogens, as well as an hereditary predisposition. The importance of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) in Puerto Rico, its molecular genetics, diagnostic criteria, and management will be discussed
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology , Colorectal Neoplasms/epidemiology , Cohort Studies , Diet , Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , Colorectal Neoplasms/etiology , Colorectal Neoplasms/genetics , Pedigree , Puerto Rico/epidemiology , Registries , Risk FactorsABSTRACT
A total of 120 patients with dyspepsia were evaluated by endoscopy to determine the prevalence of Helicobacter pylori in the gastric antrum in 1988. It was found that duodenal ulcer and gastric ulcer were highly associated with this bacteria. Also statistically significant association between H.p. and active gastritis was observed